منابع مشابه
Autoimmunity in Chagas heart disease.
The possibility that cardiac autoimmunity contributes to the pathogenesis of Chagas heart disease is controversial. In this paper, we address the following questions regarding the genesis of autoimmunity in Chagas heart disease: (i) What mechanism(s) are potentially responsible for the generation of self-directed antibodies and lymphocytes? (ii) What is the evidence that any of these mechanisms...
متن کاملChagas' disease and the autoimmunity hypothesis.
The notion that the pathology of Chagas' disease has an autoimmune component was initially based on the finding of circulating antibodies binding heart tissue antigens in patients and mice chronically infected with Trypanosoma cruzi. Later, T lymphocytes reactive with heart or nerve tissue antigens were found in chagasic mice and patients, extending the concept to include cell-mediated immunity...
متن کاملCardiac myosin autoimmunity in acute Chagas' heart disease.
Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulation of self-reactive cells. However, preliminary reports suggest that autoimmu...
متن کاملPathogenesis of chagas' disease: parasite persistence and autoimmunity.
Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles integrate mainly into retrotransposons at...
متن کاملThe Contribution of Autoimmunity to Chagas Heart Disease
There are many potential mechanisms underlying the pathogenesis of chagasic heart disease. The frequent absence of parasites from the inflamed heart tissue of chronically infected individuals suggests that the disease may be, in part, autoimmune in nature. Mechanisms to explain the induction of T. cruzi induced autoimmunity include (i) polyclonal lymphocyte activation, induced by the parasite, ...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1987
ISSN: 0074-0276
DOI: 10.1590/s0074-02761987000500011